引言我们的基因组每时每刻都在遭受着来自紫外线（UV）、化学物质以及自身代谢产物的攻击。为了维持遗传信息的完整性，细胞进化出了一套令人叹为观止的防御机制——核苷酸切除修复（Nucleotide Excision Repair, NER）。这套机制的失灵，直接导致了着色性干皮病（Xeroderma Pigmentosum, ...

在我们的细胞核中，DNA虽然受到严密包裹与保护，但这种保护并非绝对。无论是正常代谢过程产生的副产物，还是外界的辐射和化学物质等压力，都可能对DNA造成损伤。细胞依赖一整套精密的DNA修复系统来应对这些威胁，一旦修复机制失效，积累的DNA损伤便会破坏细 ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

UK: A recent study finds that acute exercise suppresses colorectal cancer progression by altering the circulating proteome, ...

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among the most dangerous forms of DNA damage and immediately trigger the cell's ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

DNA can be damaged by normal cellular processes as well as external factors such as UV radiation and chemicals. Such damage can lead to breaks in the DNA strand. If DNA damage is not properly repaired ...

Researchers have uncovered answers that provide the detail to explain two specific DNA repair processes that have long been in question. Researchers from the University of Birmingham have uncovered ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by researchers at Goethe University Frankfurt, part of the Rhine-Main University ...